Zopiclone metabolises to two distinct metabolites: N-oxide-zopiclone, and N-desmethyl-zopiclone . Once ingested, zopiclone becomes approximately 80% bioavailable , with between 40-80% of zopiclone being bound to plasma proteins . Furthermore, the N-oxide-zopiclone metabolite has been found to exhibit pharmacological activity in the body; with the N-desmethyl-zopiclone metabolite showing no pronounced activity [8]. The elimination half-life of zopiclone, along with its active metabolite, has been noted as being between 3.5-6.5 hours . Other zopiclone reviews have indicated half-life of 5.1 hours . Zopiclone, along with zolpidem and zaleplon, is a prescription-only medicine (POM).

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